| 摘要 |
About 50 title compds. I (e.g., R = H, Me, -CH2CN, diethylaminoethyl ; R1 = H, Me, iso-Bu, iso-Pr, Ph ; R2 = H, Me ; R3 = H, carbobenzoxy, trityl, phthalyl; A = Ph, PhCl, PhF ; B = PhCl), useful as sedatives and muscl relaxants with LD50 1000 mg/kg orally in mice, were prepd. by peptide condenstion of amine(II) and glycine(III) (5 different methods). Thus, Trityl-Gly-Gly in hexamethyl phosphoric triamide was treated with SOCl3 flowowed by addn. of 2-amino-5-chlorobenzo and recrystallization to give I (R = R2=R3=H; A = PH; B = C1C6H3)
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