PROCESS OF PREPARING OF ISOXAZOLE DERIVATIVES

摘要

1,2-benzisoxazoles derivs. I, R1 = H, halogen, C1-4 alkyl, C1-4 alkoxy, nitro, CF3 ; R2 = H, C1-4 alkyl, carboxy C1-4 alkyl, cyano C1-4 alkyl, -CH(R3) COOH, CH2COOR3, -CH(R3)COOR3 (R3 = C1-4 alkyl), useful as inflammation inhibitors, were prepd. by cyclization of II Q = hydroxyl, amino acyloxy, sulfonyloxy, R4 = halogen, formula-OM (M = H, NH3, Ia-IIa Group metal) under base condition.