| 发明名称 |
HYDROMORPHONE AND NALOXONE FOR TREATMENT OF PAIN AND OPIOID BOWEL DYSFUNCTION SYNDROME |
| 摘要 |
The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain. |
| 申请公布号 |
US2016296516(A1) |
申请公布日期 |
2016.10.13 |
| 申请号 |
US201415036735 |
申请日期 |
2014.11.13 |
| 申请人 |
EURO-CELTIQUE S.A. |
发明人 |
DANAGHER Helen Kathleen;MOHAMMAD Hassan;WALDEN Malcolm;HAYES Geoffrey Gerard;WHITEHOUSE Jonathon Oliver;KRISHNAMURTHY Thinnayam Naganathan;VARGAS RINCON Ricardo Alberto |
| 分类号 |
A61K31/485;A61K9/48;A61K9/00 |
主分类号 |
A61K31/485 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A combination of hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof in a weight ratio corresponding to about 1:2 of hydromorphone HCl:naloxone HCl for use in the treatment of pain in a patient, by orally administering hydromorphone or a pharmaceutically acceptable salt thereof in a daily amount corresponding to from and including about 2 mg up to and including about 64 mg of hydromorphone hydrochloride, and naloxone or a pharmaceutically acceptable salt thereof in a daily amount corresponding to from and including about 4 mg up to and including about 128 mg of naloxone hydrochloride. |
| 地址 |
Luxembourg LU |
