| 发明名称 | Plague vaccine | ||
| 摘要 | The application relates to a Yersinia pseudotuberculosis cell, which comprises nucleic acid coding for expression of at least one Yersinia pestis Caf1 polypeptide or of at least one antigenic fragment of Yersinia pestis Caf1, more particularly to an attenuated Y. pseudotuberculosis cell, which expresses the Y. pestis capsule. Said Y. pseudotuberculosis cell is exceptionally efficient in protecting against both bubonic plague and pulmonary plague. | ||
| 申请公布号 | US9492524(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201214419925 | 申请日期 | 2012.08.07 |
| 申请人 | INSTITUT PASTEUR | 发明人 | Carniel Elisabeth;Demeure Christian;Derbise Anne |
| 分类号 | A61K39/02;C12N1/36;A61K39/00 | 主分类号 | A61K39/02 |
| 代理机构 | Law Office of Salvatore Arrigo and Scott Lee, LLP | 代理人 | Law Office of Salvatore Arrigo and Scott Lee, LLP |
| 主权项 | 1. A genetically attenuated Yersinia pseudotuberculosis cell, wherein one or more genes selected from HPI, yopK and psaA are deleted or inactivated, and wherein nucleic acid coding for expression of at least one Yersinia pestis Caf1 polypeptide at the surface of said Y. pseudotuberculosis cell is integrated into the chromosome of said Y. pseudotuberculosis cell. | ||
| 地址 | Paris FR | ||