| 摘要 |
N-substituted benzoic amides (I; A,R = C1-5 alkyl; Z = H, sulfomoyl) having good antiemetic and psychotropic action, were prepd. step by step. (1) VII and HX(X= Br, I) were reacted to give VIII. (2) VIII was treated with SOCl2 to give II, if necessary, II was converted to free base or acid addition salt.(3) II or their salt were reacted with RNH2(R = lower alkyl) at 0≦̸C ˜room temp. to give IV.(4) I was obtained by heating IV.
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