7-Substd phenyl glycinamido-3-thiosubstd cephem derivs - as broad spectrum antibacterial agents

摘要

Cpds. (I): (where R1 is NO2, alkoxy, alkanesulphonamido, alkylaminosulphonamido, alkylureido or alkylthioureido; R2 is H or OH or when R1 is NO2 or alkoxy, R2 is OH; R3 is H or a thioheterocyclic group opt. substd. by one or more alkyl groups or when R1 is alkoxy and R2 is OH, R3 is H; X is amino or protected amino and M is H or a non toxic cation) are prepd. by acylation of a 7-amino-3-thio substd.-5-cephem-4-carboxylic acid deriv. or by reacting a 7-substd. phenyl glycinamido. Amino cephalosporanic acid with a heterocyclyl mercaptan.