Photoactivatable crosslinker

摘要

Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

主权项

1. A method of coating a support surface with a degradable linking agent in order to provide the support surface with one or more latent reactive groups, the method comprising:
a) providing the support surface; b) applying to the support surface the degradable linking agent,
wherein the degradable linking agent comprises a formula selected from: wherein Photo1 and Photo2, independently, represent a photoreactive group; n is an integer between 1 and 10; and R1-R4 are independently cyclic, linear or branched, saturated or unsaturated, aromatic or heteroaromatic, a photoreactive group, hydroxyl or salt thereof, or a combination thereof; wherein Photo1 and Photo2, independently, represent one or more photoreactive groups; and R1 and R2 are independently a photoreactive group, hydroxyl or salt thereof, or a combination thereof; wherein Photo1 and Photo2, independently, represent one or more photoreactive groups and R is hydroxyl or a salt thereof, or a combination thereof;and wherein Photo1 and Photo2, independently, represent a photoreactive group, Y represents a linker that is null, an amine, an ether, linear or branched C1-C10 alkyl, or a combination thereof; and R1 and R2 are independently a photoreactive group, hydroxyl or salt thereof, cyclic, linear or branched hydrocarbon, saturated or unsaturated, aromatic or heteroaromatic, or a combination thereof; and c) illuminating the degradable linking agent upon the support surface under conditions suitable to activate a first photoreactive group to attach the degradable linking agent to the support surface, wherein a second photoreactive species remains unbound to the support surface and is able to revert to a latent reactive state.