| 摘要 |
<p>A bisbiguanide compound of the formula:-
<Chemistry id="chema01" num="0001"><Image id="ia01" he="14" wi="81" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>ora tautomerthereof, wherein R', R', R' and R<Sup>1</Sup> which may be the same ordifferent, are each hydrogen, a 1-16C alkyl radical, a 2-16C alkoxyalkyl radical, a 3-12C cycloalkyl radical, a (3-12C cycloalkyl)-(1-4C alkyl) radical, or an optionally substituted phenyl or phenyl (1-4C alkyl) radical, or R' and R<Sup>2</Sup> and the nitrogen atom to which they are attached, or R' and R' and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical each of which may bear 1-3C alkyl substituents; each of R<Sup>6</Sup> and R<Sup>7</Sup>, which may be the same or different, is hydrogen or a 1-8C alkyl radical; and X is a substituted ethylene or ethylidene radical of the formula:-
<Chemistry id="chema02" num="0002"><Image id="ia02" he="9" wi="82" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><Chemistry id="chema03" num="0003"><Image id="ia03" he="6" wi="83" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>reading from left to right in formula V above, wherein Y is an oxygen or sulphur atom and R<Sup>5</Sup> is a 1-16C alkyl, 3-12C cycloalkyl, (3-12C cycloalkyl)-(1-4C alkyl), optionally substituted phenyl or optionally substituted phenyl (1-4C alkyl) radical, and the acid addition salts thereof, processes for their manufacture and antibacterial and antifungal compositions and methods using said compounds.</p> |
