| 摘要 |
<p>Bacterial growth associated with the use of biomedical indwelling devices can be combatted by the use of isothiazolones. An appropriate biomedical device comprises an elastomer having a Tg below 25 DEG C having incorporated therein or coated thereon an effective amount of isothiazolone of the formula:
<CHEM>
wherein Y is hydrogen, unsubstituted or substituted C4-C18 alkyl, unsubstituted or substituted C4-C18 alkenyl or alkynyl, an unsubstituted or substituted C3-C12 cycloalkyl, unsubstituted aralkyl of 6-10 carbon atoms, or unsubstituted or substituted aryl of 6-10 carbon atoms; R is hydrogen, halo, or C1-C4 alkyl; R<1> is hydrogen, halo, or C1-C4 alkyl. Generally therapeutically effective amounts are in the range 0.03 to 5 percent by weight isothiazolone based on elastomer. </p> |
