发明名称 |
Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
摘要 |
The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravazation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I. |
申请公布号 |
US9457019(B2) |
申请公布日期 |
2016.10.04 |
申请号 |
US201414535900 |
申请日期 |
2014.11.07 |
申请人 |
Deciphera Pharmaceuticals, LLC |
发明人 |
Flynn Daniel L.;Kaufman Michael D.;Smith Bryan D.;Rudoltz Marc |
分类号 |
A61K38/00;A61K31/4709;C07D401/14;A61K45/06;A61K31/337;A61K31/351;C07K16/40;A61K31/357 |
主分类号 |
A61K38/00 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP |
主权项 |
1. A method of blocking breast tumor growth, invasiveness, dissemination, metastasis, or increasing survival in breast cancer in patients comprising administering to a patient whose tumor microenvironment expresses TIE2 kinase in TIE2-expressing macrophages, an effective amount of a composition of Formula I wherein
n is an integer from 0 to 7;X is the basic radical of a pharmaceutically acceptable salt;provided that when n is 0, the composition of Formula I is the parent free base; in a dosing regimen sufficient to block TIE2 kinase in tumor microenvironment TIE2-expressing macrophages. |
地址 |
Lawrence KS US |