| 主权项 |
1. A method of treating an auditory impairment associated with cochlear outer hair cell damage, dysfunction or loss in a subject comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester selected from the group consisting of:
(a) 3,4-O-dicaffeoylquinic acid, (b) 3,5-O-dicaffeoylquinic acid, (c) 1,3-O-dicaffeoylquinic acid, (d) 4,5-O-dicaffeoylquinic acid, (e) 1,5-O-dicaffeoylquinic acid, (f) 3-O-feruloylquinic acid, (g) 4-O-feruloylquinic acid, (h) 5-O-feruloylquinic acid, (i) 1-O-caffeoylquinic acid, (j) 3-O-caffeoylquinic acid, (k) 4-O-caffeoylquinic acid, (l) 5-O-caffeoylquinic acid, (m) (1S,3R,4R,5R)-3-[3-(3,4-dihydroxyphenyl)-3R-hydroxypropanoyl]-1,4,5-trihydroxycyclohexanecarboxylic acid, (n) (1S,3R,4R,5R)-3-[3-(3,4-dihydroxyphenyl)-3S-hydroxypropanoyl]-1,4,5-trihydroxycyclohexanecarboxylic acid, (o) (1S,3R,4R,5R)-5-[3-(3,4-dihydroxyphenyl)-3R-hydroxypropanoyl]-1,3,4-trihydroxycyclohexanecarboxylic acid, (p) (1S,3R,4R,5R)-5-[3-(3,4-dihydroxyphenyl)-3S-hydroxypropanoyl]-1,3,4-trihydroxycyclohexanecarboxylic acid, (q) (1S,3R,4R,5R)-4-[3-(3,4-dihydroxyphenyl)-3R-hydroxypropanoyl]-1,3,5-trihydroxycyclohexanecarboxylic acid, (r) (1S,3R,4R,5R)-4-[3-(3,4-dihydroxyphenyl)-3S-hydroxypropanoyl]-1,3,5-trihydroxycyclohexanecarboxylic acid, (s) cis-5-O-caffeoylquinic acid, (t) 3-O-caffeoylquinic acid lactone, (u) 3-O-caffeoyl-4-O-feruloylquinic acid, and (v) a pharmaceutically acceptable salt thereof, so as to restore cochlear outer hair cell function, thereby treating the auditory impairment associated with cochlear outer hair cell damage, dysfunction or loss in the subject. |
