| 摘要 |
The in vitro chemotactic activity of recombinant protein compositions is a predictive test for in vivo immunogenicity. Recombinant synthesis methods and subsequent purification or processing techniques are modified in the light of the chemotactic assay results in order to reduce or enhance the in vivo immunogenicity of the compositions. The invention ameliorates a major cost and source of uncertainty in the development of recombinant protein compositions. Immunogenicity of substances in vivo is modulated by binding chemotactic polypeptides thereto.
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