Topical cromolyn formulations

摘要

The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a cromoglycic acid compound. Methods of treatment, and methods of preparing the topical composition are also provided.

主权项

1. A topical administration composition comprising:
(A) a cromolyn component selected from the group consisting of cromolyn and pharmaceutically acceptable salts thereof; (B) a delivery agent selected from the group consisting of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid, 8-(2-hydroxybenzoylamino)-octanoic acid 2-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyoxy}ethyl ester, and pharmaceutically acceptable salts thereof; (C) a semi-aqueous vehicle which is unconjugated PEG/water; and (D) (a) an excipient,
(b) a cream,(c) an ointment base,(d) a viscosity building agent,(e) a moisturizer,(f) a preservative,(g) a formulation vehicle, or(h) any combination thereof,wherein the topical administration composition provides a higher epidermal layer concentration of the cromolyn component over 8 hrs or 48 hrs after a single administration than a similar topical composition without the delivery agent compound.