| 发明名称 |
A PROCESS FOR THE PREPARATION OF 3-(4'-BROMOBIPHENYL-4-YL)TETRALIN-1-ONE |
| 摘要 |
<p>A new process for the preparation of a 3-(4'-bromobiphenyl-4-yl)tetralin-1-one known as a key intermediate for the production of rodenticides and clinical medicines is provided. The title compound is prepared from P-bromobiphenylbenzylketone in three steps, wherein one of key inventions is dehydroxylation of 3-(4'-bromobiphenyl)-3-hydroxy-4-phenylbutyric acid ethyl ester using trialkylsilane in trifluoroacetic acid. This new process offers a high yield with a facile way and is more suitable for a commercial production than the prior art methods.</p> |
| 申请公布号 |
IN166720(B) |
申请公布日期 |
1990.07.14 |
| 申请号 |
IN1988CA39519 |
申请日期 |
1988.05.16 |
| 申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
KIM, IN O.;LEE, SANG GEE |
| 分类号 |
C07C45/66;B01J27/06;B01J27/16;B01J31/02;B01J31/04;C07B61/00;C07C45/00;C07C45/46;C07C49/323;C07C49/697;C07C49/813;C07C51/00;C07C51/09;C07C51/377;C07C57/58;C07C67/00;C07C67/343;C07C69/14;C07C69/732;(IPC1-7):C07C45/00;C07C45/72;C07C45/68 |
主分类号 |
C07C45/66 |
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