PROCESS FOR THE PREPARATION OF SALT FREE, WATER FREE 3-ISOTHIAZOLONE COMPOUNDS

摘要

A process for preparing a 3-isothiazolone of the formula wherein Y is selected from the group consisting of alkyl or substituted alkyl of 1 to 10 carbon atoms; unsubstituted or halogen-substituted alkenyl or alkynyl of 2 to 10 carbon atoms; and aralkyl or halogen-, lower alkyl-, or lower alkoxy-substituted aralkyl of up to 10 carbon atoms; X is hydrogen or a (C1-C2) alkyl; and X1 is hydrogen, chlorine, or a (C1-C2) alkyl; comprising (a) reacting anhydrous ammonia with an isothiazolone salt of the formula wherein Z is chlorine, bromine, sulfate or fluorosulfonate; m is 1 when Z is chlorine, bromine ot fluorosulfonate, and m is 2 when Z is sulfate; and (b) separating the resultant (NH4)mZ from the resultant free base isothiazolone is disclosed.