SKIN-ASSOCIATED LYMPHOCYTES AND MARKERS

摘要

2096117 9208490 PCTABS00013 Regulation of hematopoietic cell association with skin during chronic inflammation may be modulated by the use of agents which selectively identify and target skin associated leukocytes or inhibit the binding of a skin associated antigen (CLAM-1) with receptors present in cutaneous associated cells. The agents may be used for diagnosis of inflammations and malignancies associated with the presence of the CLAM-1 carrying hematopoietic cells at cutaneous sites. By employing lymphocytes or other antibodies or cytotoxic agents, inflammatory disorders mediated by cutaneous lymphocytes or other T-cells or skin associated T-cell malignancies may be treated. Cutaneous inflammation and lymphoid neoplasia can be characterized and modified by the agents which selectively identify and target skin-associated T-cells or which inhibit the binding of CLAM-1 with receptor(s) present in cutaneous associated cells.