A TRAMADOL N-OXIDE MATERIAL, ENANTIOMERS AND COMPOSITIONS THEREOF, AND THEIR USE

摘要

This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol Noxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol Noxide is also subject to less side-effects as compared to pure opiate based compositions, suoh as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.