摘要 |
PURPOSE:To industrially obtain L-lysine at a low cost by culture of L-lysine- productive microorganisms belonging to Corynebacterium glutamicum and also resistant to iodothyronine. CONSTITUTION:L-lysine-productive microorganisms belonging to Corynebacterium glutamicum and also resistant to iodothyronine [ e.g. Corynebacterium glutamicum H-8241 strain (FERM-BP-3594)] are cultured in a medium to produce and accumulate L-lysine in the cultured product followed by collecting the objective L-lysine from the cultured product. The culture is pref. made aerobically at 28-36 deg.C in an about neutral state normally for 1-7 days. The microorganisms can be produced by e.g. mutational treatment such as ultraviolet light irradiation of L-lysine-productive bacteria. |