| 摘要 |
<p>An apparatus and method for the inactivation of infectious organisms such as viruses, bacteria, fungi and protozoa, and especially for the inactivation of human immunodeficiency virus in proteinaceous material such as blood and blood products. This process is accomplished without adversely affecting the normal physiological activity of the material, by contacting it for a time interval of only about 16 seconds with an ozone-oxygen mixture having an ozone concentration of only about 27 νg/ml. The system (10) includes a mobile cart (11) supporting an oxygen tank (15) that is regulated by valve (16) and is connected to an ozone generator (18) by tubing (17). The ozone-oxygen mixture exiting the ozone generator (18) is supplied via conduit (19) to the lower end of gas-liquid contact apparatus (20). The ozone-oxygen mixture has a resonant frequency of 7.83 Hz. Blood is introduced through a first pump (26) into the upper end of gas-liquid contact apparatus (20) and cascades down to a pool (P). A second pump (27) pumps the blood through a filter (28) and back to its source. The apparatus and method of the invention provide precise control of the concentration of ozone and the contact time between the material to be treated and the ozone-oxygen mixture.</p> |
