发明名称 |
PROCESSES FOR PRODUCING 1-SUBSTITUTED-2-CYANOIMIDAZOLE COMPOUNDS |
摘要 |
A process for producing 1-substituted-2-cyanoimidazole compounds is described, which comprises (1) undergoing a reaction of a compound represented by formula (IV), hydroxylamine or a mineral acid salt thereof, and glyoxal or glyoxime to produce a compound represented by formula (III), (2) undergoing a reaction of the compound represented by formula (III) with thionyl chloride or thionyl bromide in the presence of N,N-dialkylamide to produce a reaction mixture, and then reacting the produced reaction mixture with sulfur chloride to produce a 2-cyanoimidazole compound represented by formula (II), and (3) undergoing a sulfamoylation reaction and an isomerization reaction of the 2-cyanoimidazole compound represented by formula (II) and a compound represented by formula (V) in the presence of at least one base selected from carbonates of alkali metals and bicarbonates of alkali metals and a polar solvent to produce a 1-substituted-2-cyanoimidazole compound represented by formula (I-b). The substituents in formulae are specifically defined in the specification. (IV) <IMG> <IMG> (III) <IMG> (II) Hal-SO2N(R1)R2 (V) <IMG> (I-b)
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申请公布号 |
CA2157753(A1) |
申请公布日期 |
1996.03.09 |
申请号 |
CA19952157753 |
申请日期 |
1995.09.07 |
申请人 |
ISHIHARA SANGYO KAISHA, LTD. |
发明人 |
JONISHI, HISAYOSHI;KIMURA, TOKIYA;KANAMORI, FUMIO;KANBAYASHI, SHIGEHISA;WAKABAYASHI, TOORU;FUKUI, FUMIHIRO;TAKENAKA, AKIMASA;HORIUCHI, NORIYUKI |
分类号 |
C07C45/63;C07C251/48;C07D233/54;C07D233/90;(IPC1-7):C07D233/90 |
主分类号 |
C07C45/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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