| 摘要 |
A solid composition comprises: (a) 1-70 % metoprolol (M) in a non-amorphous form; (b) 10-95 % polyethylene oxide (PEO); and (c) a balance of conventional additives, excluding basic components. An Independent claim is also included for the preparation of the above composition, comprising: (i) mixing the dry state and the metoprolol (M) and the polyethylene oxide (PEO) and optionally one or more additives; (ii) optionally adding a solvent, followed by mixing; (iii) granulating the mixture; (iv) drying the granules; (v) optionally adding one or more additives with mixing in the dry state and passing it through a sieve; (vi) optionally adding one or more additives and mixing in the dry state; (vii) compressing the mixture obtained into a pressed tablet; and (viii) optionally coating the compressed tablet. |
