摘要 |
PROBLEM TO BE SOLVED: To obtain a new heterocyclic compound having excellent human neutrophil elastase inhibiting action and useful for the prevention, treatment, or the like, of acute pulmonary diseases. SOLUTION: The objective compound is expressed by formula I [the mark *represents an asymmetric carbon atom; A and B are each a lower alkylene; D is a monocylic or bicyclic heterocyclic group of formula II (G is present or absent; D1 is methylene or ethylene; the dotted line is a ring-constitution element); R1 and R2 are each a lower alkyl; R3 and R4 are each H, OH or together form an oxo group; R5 is a group of formula III (X1 and X2 are each a halogen; Y1 is H, a halogen, a lower alkoxycarbonyl, or the like; (n) is 0-2; (m) is 0-5)], e.g. S-[2-(3-carboxymethyl-2-oxo-1-imidazolidinyl)acetyl]-valyl- N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-L-prolinamide. The compound of formula I can be produced e.g. by reacting a compound of formula IV with a compound of formula V (W is a group bondable with amino group) in the presence of a base such as triethylamine.
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