METHOD FOR DEPOSITING DIASTEREOMER CRYSTAL

摘要

PROBLEM TO BE SOLVED: To provide the crystals of a diastereomer useful as an intermediate for medicines such as paroxetine in a high purity and in a high yield. SOLUTION: This method for depositing the crystals of a diastereomer by reacting a racemic trans-3-hydroxymethyl-4-R1-piperidine compound (wherein R1 is phenyl group which may have one or more substituents) with an optically active organic acid to produce a diastereomer as the organic acid salt of the d-isomer and a diastereomer as the organic acid salt of the l-isomer and then dedepositing either of the diastereomers as the crystals, characterized by depositing the crystals of the target diastereomer in acetone-water solvent.