发明名称 |
Gastrin receptor-avid peptide conjugates |
摘要 |
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
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申请公布号 |
US2002176819(A1) |
申请公布日期 |
2002.11.28 |
申请号 |
US20020122611 |
申请日期 |
2002.04.12 |
申请人 |
HOFFMAN TIMOTHY J.;VOLKERT WYNN A.;LI NING;SIECKMAN GARY;HIGGINBOTHAM C.A. |
发明人 |
HOFFMAN TIMOTHY J.;VOLKERT WYNN A.;LI NING;SIECKMAN GARY;HIGGINBOTHAM C.A. |
分类号 |
G01N33/566;A61K38/00;A61K51/00;A61K51/08;A61P35/00;C07F5/00;C07F15/00;C07K7/06;C07K7/08;C07K14/575;(IPC1-7):A61K51/00;A61M36/14 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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