| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new derivatives of imidazole of the formula (I): wherein symbols have the following values: R1 means -CaH2a-phenyl wherein phenyl moiety is not substituted; a = 0; or R2 and R3 mean independently of one another CO-R(6), O-(alkylene with 2, 3 or 4 carbon atoms)-OR(17) wherein R(17) means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(6) means hydrogen atom; R4 and R5 mean independently of one another hydrogen atom, F, Cl, Br, J, S(O)p-R(16) or O-(alkylene with 2, 3 or 4 carbon atoms)-OR(33); p = 2; R(16) means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R(33) means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, and to their physiologically acceptable salts also under condition that at least one of residues R2 or R3 means O-(alkylene with 2, 3 or 4 carbon atoms)-OR(17). Also, invention relates to pharmaceutical composition used for inhibition of Na+-dependent bicarbonate-chloride exchange based on these compounds. Invention provides preparing new compounds and pharmaceutical composition based on thereof for aims therapy and/or prophylaxis of diseases wherein the primary or secondary cause is the cell proliferation. ^ EFFECT: valuable medicinal properties of compounds. ^ 9 cl, 4 ex |
