发明名称 |
Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4 positive T cells |
摘要 |
GB virus C (GBV-C or hepatitis G virus) is a recently described flavivirus that frequently leads to chronic viremia in humans. Although associated with acute post-transfusion hepatitis, it is not clear if GBV-C is pathogenic for humans. A full-length cDNA was constructed from the plasma of a person with chronic GBV-C viremia. Peripheral blood mononuclear cells (PBMCs) transfected with full-length RNA transcripts from this GBV-C clone resulted in viral replication, demonstrating an isolated infectious GBV-C nucleic acid molecule. In addition to composition involving an isolated infectious GBV-C nucleic acid molecule, the present invention concerns methods of inhibiting and treating HIV infections.
|
申请公布号 |
US6870043(B2) |
申请公布日期 |
2005.03.22 |
申请号 |
US20010828498 |
申请日期 |
2001.04.05 |
申请人 |
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
XIANG JINHUA;WUENSCHMANN SABINA;SCHMIDT WARREN;STAPLETON JACK |
分类号 |
A61K35/76;A61P31/18;C07K14/18;C12N7/00;(IPC1-7):C07H21/04 |
主分类号 |
A61K35/76 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|