Un proceso de hidrogenación de cetoésteres

摘要

The invention relaters to a process for the production of an (S)- or (R)-4-halo-3-hydroxybutyrate ester, comprising
reacting a 4-haloacetoacetate ester in the presence of a solvent with hydrogen
in the presence of a catalyst of the formula [RuXArY]X, wherein
X is halogen, preferably Cl, or OAc, allyl or ClO 4 ,
Y is BINAP, or a derivative of BINAP having at least one aromatic ring substituted with an alkyl group,
Ar is an arene, preferably cymene, benzene, xylene or toluene. The invention also relates to a method for the production of L-carnitine.