| 摘要 |
1388790 [Alpha - (3 - trifluoromethylphenoxy) - 4 - chlorobenzyl] - heterocycles MERCK & CO Inc 5 April 1973 16362/73 Heading C2C The invention comprises compounds having the general formula wherein R is a 5-membered heterocycle containing from 2 to 4 hetero atoms, the hetero atoms being oxygen and/or nitrogen, and non- toxic, pharmaceutically acceptable salts thereof. They may be prepared by cyclizing a compound of the formula wherein R<SP>1</SP> is beta-hydroxyethylaminocarbonyl, beta,beta-dichloroethylaminocarbonyl, or iminoazidomethyl. The compounds of the invention reduce the concentration of cholesterol, triglycerides and other lipids in blood serum and are useful in the treatment of atherosclerosis, and may be administered orally or parenterally in admixture with a pharmaceutical diluent or carrier.
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