发明名称 |
FREMGANGSMAATE TIL FREMSTILLING AV CEFALEXIN ELLER HETACEFALEXIN |
摘要 |
<p>The antibacterial agent cephalexin is prepared from readily available hetacillin by the consecutive steps of nitrosation or formylation to give N-nitroso- or N-formyl-hetacillin, oxidation as with NaIO4 below pH 5 to give the corresponding sulfoxide, rearrangement by heat, preferably with acid present, to give N-nitroso- or N-formylhetacephalexin and finally cleavage to give cephalexin as by zinc and acetic acid or Raney nickel and hydrogen or, preferably, hydrogen chloride in dioxane.</p> |
申请公布号 |
NO145954(B) |
申请公布日期 |
1982.03.22 |
申请号 |
NO19710002626 |
申请日期 |
1971.07.08 |
申请人 |
BRISTOL-MYERS CO, |
发明人 |
GOTTSTEIN, WILLIAM JOSEPH,;CHENEY, LEE CANNON, |
分类号 |
C07D501/04;A61K;A61K31/545;A61K31/546;C07D;C07D499/80;C07D501/10;C07D501/22;C07D501/58;C07D501/60;C07G11/00;(IPC1-7):07D501/10 |
主分类号 |
C07D501/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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