摘要 |
<p>A process for the esterification of alpha -L-aspartyl-L-phenylalanine which comprises contacting optionally N-protected alpha -L-aspartyl-L-phenylalanine with an alcohol in the presence of a proteolytic enzyme having specific esterase activity in an aqueous alcohol medium at a pH of from 4 to 7, the alcohol concentration being sufficient to reverse the hydrolytic activity of the protease, and optionally removing the N-protecting group is disclosed. The alpha -L-aspartyl-L-phenylalanine esters produced may be used as artificial sweeteners.</p> |