发明名称 |
VERFAHREN ZUR HERSTELLUNG VON 7-OXO-1-AZABICYCLO(3,2,0)HEPT-2-ENE-2-CARBONSAEURE-DERIVATEN |
摘要 |
<p>7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives of formula (I): <IMAGE> (I) (in which:) R1 represents a hydrogen atom or an optionally substituted alkyl group; X represents an oxy group, a thio group, a sulphinyl group or a sulphonyl group; A represents a bivalent for trivalent saturated aliphatic hydrocarbon group; p is 1 (when A is bivalent) or 2 (when A is trivalent); R2 represents an azido, nitro or cyano group or one of the groups of formula <IMAGE> m and n are the same or different and each is 0 or 1; R represents an amidino group or a group of formula R4, -N(R4)2 or -YR4, B represents a group of formula <IMAGE> D represents a group of formula <IMAGE> (provided that, where m and n are both 1, the groups represented by B and D must be different); R4 represents a hydrogen atom or an alkyl group and, where there are 2 or more groups represented by R4, they may be the same or different, and Y represents an oxygen atom or a sulphur atom; and R3 represents a carboxy group or a protected carboxy group) and pharmaceutically acceptable salts thereof are valuable antibiotics and may be prepared by a process which includes heating a corresponding phosphorus-ylide compound.</p> |
申请公布号 |
DD156911(A5) |
申请公布日期 |
1982.09.29 |
申请号 |
DD19810228019 |
申请日期 |
1981.03.03 |
申请人 |
SANKYO CO LTD SANKYO CENTRAL RESEARCH LABORATORIES,JP |
发明人 |
HIRACKA,TETSUO,JP;KOBAYASHI,TAKEO,JP;ISHIDA,NOBORU,JP;SUGAWARA,SHINICHI,JP |
分类号 |
C07D477/00;A61K31/397;A61K31/40;A61P31/04;C07D205/08;C07D477/14;C07F7/10;C07F7/18;C07F9/568;(IPC1-7):C07D487/04 |
主分类号 |
C07D477/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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