| 摘要 |
This invention relates to novel 20-deoxyrosaramicin derivatives of the general formula
<CHEM>
wherein A represents a double bond between the carbon atoms of positions 12 and 13 or, together with the carbon atoms of positions 12 and 13, an oxirane ring; Z is a group of formula IIa or IIb,
<CHEM>
wherein Q is CRR<1>, NR, O, S, SO2,
<CHEM>
CROR<1>, CROC(O)R<1>, CHCOOR, CHCONRR<1> or CRCN; n is zero, 1 or 2;
and the pharmaceutically acceptable acid addition salts thereof.
These new compounds possess antibacterial activity. |
