| 摘要 |
The present invention relates to peptide derivatives of the general formula: R-X-Y-Statyl1-Ala-Statyl2-R'(1), in which: Statyl1 and Statyl2 represent the radical derived from the aminoacid statine, R denotes a hydrogen atom or an acylating group attached to the terminal amino group of the aminoacid X-, X and Y, which are identical or different, denote aminoacids of the L or D configuration if a center of asymmetry exists in the molecule, and optionally protected in their side chain, with the proviso that X and Y cannot simultaneously denote valine, and R' denotes OH, O-lower alkyl, NH2 or a group NH-R1, in which R1 represents a lower alkyl or lower aralkyl group. It also relates to a process for the preparation of the products of the formula (1) and to the medicaments containing a product of the formula (1) as the active principle. |
