| 摘要 |
Novel compounds are described having the formula <IMAGE> wherein Z is <IMAGE> R1 is hydrogen or a C1-C4 lower alkyl; R2 is hydrogen, a C1-C4 lower alkyl, hydroxy-R8-, lower alkyl-R8-, mercapto-R8-, cyclohexyl, cyclopentyl, phenyl, phenyl-R8-, indolyl-R8-, carboxy-R8-, amino-R8- or carbamoyl-R8-, wherein R8- is a divalent C1-C6 straight chain parafinic moiety; R3 is hydrogen or C1-C4 lower alkyl; R4 is hydrogen, lower alkanoyl, benzoyl or phenyl-substituted-lower alkanoyl; R5 is hydrogen or a C1-C4 lower alkyl; R1, R2 and R5 excluding tertiary butyl; ARYL is 1-naphthyl, 2-naphthyl, 4-chloro-1-naphthyl, 4-methoxy-1-naphthyl, 5,6,7,8-tetrahydro-1-naphthyl, 5,6,7,8-tetrahydro-2-naphthyl, 4-biphenylyl, 5-indanyl, 4-indanyl, phenyl, or substituted phenyl moieties having the formula <IMAGE> wherein R6 is fluoro, chloro, bromo, trifluoromethyl, cyano, phenoxy, halophenoxy, phenylthio, halophenylthio, a C1-C4 lower alkyl or a C1-C4 lower alkoxy, and R7 is chloro, fluoro, bromo, a C1-C4 lower alkyl or a C1-C4 lower alkoxy; and where m is an integer of zero, one or two; including individual optically active isomers; racemic mixtures thereof; non-toxic pharmacologically-acceptable salts of the foregoing; and mixtures of the foregoing. Processes of preparing such compounds are also described. Such compounds are useful in ameliorating hypertension in mammals.
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