Phenylaminobenzenealkanols and preparation.

摘要

Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="48" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R'is hydrogen or lower-alkyl; R"is hydrogen, lower-alkyl or halo; and Y is CnH2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein -Y-OH is replaced by -COCH<Sub>3</Sub>. The invention also relates to the novel benzyl ether intermediates.