| 发明名称 |
MULTILAYERED NANOPARTICLE AND METHODS OF MANUFACTURING AND USING THE SAME |
| 摘要 |
The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA. |
| 申请公布号 |
US2016319280(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201415104123 |
申请日期 |
2014.12.09 |
| 申请人 |
NANYANG TECHNOLOGICAL UNIVERSITY ;SINGAPORE HEALTH SERVICES PTE LTD |
发明人 |
Venkatraman Subramanian;Wong Tzee Ling Tina;Neu Bjorn |
| 分类号 |
C12N15/113;A61K31/713;A61K9/50 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. Multilayered nanoparticle for delivery of RNA to a cell, the nanoparticle comprising: a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the number of layers is 2 or more and wherein at least one of the negatively charged polymer layers comprises or consist of RNA. |
| 地址 |
Singapore SG |
