发明名称 |
Oxidation-resistant interferon-beta muteins and their production; formulations containing such muteins. |
摘要 |
<p>A biologically active reference (e.g. human) IFN-Beta protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionine residue susceptible to chloramine T or peroxide oxidation, where additional, non-susceptible methionine residues are not so-substituted.</p> |
申请公布号 |
EP0260350(A1) |
申请公布日期 |
1988.03.23 |
申请号 |
EP19860306895 |
申请日期 |
1986.09.05 |
申请人 |
CETUS CORPORATION |
发明人 |
WANG, ALICE M.;SHAKED, ZE'EV |
分类号 |
A61K38/00;C07K14/565 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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