发明名称 |
ANALOGIFREMGANGSMAATE VED FREMSTILLING AV TERAPEUTISK AKTIVE 6-HYDROXYALKYL-2-(SUBSTITUERT)THIO-PENEM-3-CARBOXYLSYRER |
摘要 |
<p>Penems of the formula I <CHEM> in which R is hydrogen or an organic radical, G is hydroxyloweralkyl and X is hydrogen, a pharmaceutically acceptable salt forming group or a metabolisable ester group, or a protecting group are disclosed. Process for their preparation involves reacting a compound II <CHEM> in which R1 and R2 are protected carboxy groups and Met is a thiophilic metal with a thiocarbonyl III S=C(Y)2 III in which Y is a leaving group, followed by removal of one of R1 and R2 to give a compound of formula I in which R is H together with its thione tautomer. Organic groups R can be introduced into the so-obtained compound by known methods. Alternatively the compound of formula I in which R is hydrogen can be made by intra-molecular cyclisation of the compound IV. <CHEM> G, Y and R2 being as previously defined. Various novel penems are also disclosed as well as three other processes for their preparation.</p> |
申请公布号 |
NO165073(B) |
申请公布日期 |
1990.09.10 |
申请号 |
NO19830004331 |
申请日期 |
1983.11.25 |
申请人 |
SCHERING CORPORATION |
发明人 |
GIRIJAVALLABHAN, VIYYOOR MOOPIL;GANGULY, ASHIT KUMAR;PINTO, PATRICK ANTHONY;VERSACE, RICHARD WILLIAM;MCCOMBIE, STUART WALTER |
分类号 |
C07D499/897;A61K31/425;A61K31/43;A61P31/04;C07D205/08;C07D205/09;C07D233/54;C07D409/12;C07D499/00;C07D499/88;C07D499/893;C07F7/08;C07F7/18;(IPC1-7):C07D499/86 |
主分类号 |
C07D499/897 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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