发明名称 PROCESS FOR PRODUCING NEW 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES
摘要 4,4-disubstd piperidine derivs of formula (I) and their acid addn and quaternary ammonium salts are new. In (I) R1 = H or C0NHR; R = H, 1-12C alkyl, 3-6C cycloalkyl or a carboxyclic 6-10C aryl or carbocycline (6-10C aryl) 1-4C alkyl opt ring substd by one or more halo, 1-4C alkyl or 1-4C alkoxy; R2 = ethynyl or C0CH3; Ph1 and Ph2 = phenyl opt substd by one or more halo, 1-4C alkyl, 1-4C alkoxy, trihalo or 0H opt esterified by a 1-4C alkansic acid; n = 1-2. - 3 Cpds (I) ie 1-(3,3-bis(4-fluorophenyl)-2-propenyl)-4 ethynyl-4-hydroxypiperidine hydrochloride, (Ib) 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-ethynyl-4-hydroxy piperidine hydrochloride (Ia) and 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-benzylcarbamoyloxy-4 ethynylpiperidine are specifically claimed.
申请公布号 HU903233(D0) 申请公布日期 1990.10.28
申请号 HU19890003233 申请日期 1989.08.10
申请人 RICHTER GEDEON VEGYESZETI GYAR RT.,HU 发明人 TOTH,EDIT,HU;TOERLEY,JOZSEF,HU;GOEROEG,SANDOR,HU;SZPORNY,LASZLO,HU;KISS,BELA,HU;PALOS,EVA,HU;GROO,DORA,HU;LASZLOVSZKY,ISTVAN,HU;LAPIS,ERZSEBET,HU;AUTH,FERENC,HU;GAAL,LASZLO,HU
分类号 A61K31/42;A61K31/445;A61P25/18;A61P25/20;A61P25/24;A61P25/26;A61P25/28;C07D211/22;C07D491/10;C07D491/113;C07D498/10 主分类号 A61K31/42
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