摘要 |
4,4-disubstd piperidine derivs of formula (I) and their acid addn and quaternary ammonium salts are new. In (I) R1 = H or C0NHR; R = H, 1-12C alkyl, 3-6C cycloalkyl or a carboxyclic 6-10C aryl or carbocycline (6-10C aryl) 1-4C alkyl opt ring substd by one or more halo, 1-4C alkyl or 1-4C alkoxy; R2 = ethynyl or C0CH3; Ph1 and Ph2 = phenyl opt substd by one or more halo, 1-4C alkyl, 1-4C alkoxy, trihalo or 0H opt esterified by a 1-4C alkansic acid; n = 1-2. - 3 Cpds (I) ie 1-(3,3-bis(4-fluorophenyl)-2-propenyl)-4 ethynyl-4-hydroxypiperidine hydrochloride, (Ib) 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-ethynyl-4-hydroxy piperidine hydrochloride (Ia) and 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-benzylcarbamoyloxy-4 ethynylpiperidine are specifically claimed. |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT.,HU |
发明人 |
TOTH,EDIT,HU;TOERLEY,JOZSEF,HU;GOEROEG,SANDOR,HU;SZPORNY,LASZLO,HU;KISS,BELA,HU;PALOS,EVA,HU;GROO,DORA,HU;LASZLOVSZKY,ISTVAN,HU;LAPIS,ERZSEBET,HU;AUTH,FERENC,HU;GAAL,LASZLO,HU |