| 摘要 |
<p>An analog of piscine GnRH is disclosed having the amino acid sequence: pGlu-His-Trp-Ser-Tyr-W-Trp-Leu-Arg-Pro-Gly-X-Y-Z wherein W represents Gly or a D-amino acid, X represents a bond, or one or more amino acids which may be the same or different, Y represents Cys or Tyr or is absent, and Z is absent or represents one or more amino acids which may be the same or different or a continuous or discontinuous peptide chain, the or each discontinuity being a non-α amino acid polyfunctional linker moiety or a retro-inverso amino acid with the proviso that when W is Gly and X and Y are absent Z is present. The analog may be conjugated to a carrier and used, for example, to delay onset of sexual maturation and enhance growth.</p> |
