METHOD OF INHIBITING PADGEM-MEDIATED INTERACTIONS USING AN INHIBITOR COMPRISING A 2,6 SIALIC ACID COMPONENT

摘要

2105997 9216612 PCTABS00016 The invention relates to a method of inhibiting (reducing or preventing) the interaction or adhesion of a PADGEM-bearing cell with a cell bearing a PADGEM ligand by contacting the PADGEM-bearing cell with an inhibitor comprising a 2,6-linked sialic acid component. By the method of the present invention, it is possible to inhibit the interaction of a PADGEM-bearing cell, such as a platelet or endothelial cell, with a cell bearing a PADGEM ligand, such as a white blood cell (leukocyte) by contacting the cell with an inhibitor comprising a 2,6-linked sialic acid residue. The invention further relates to inhibitors useful in the present method.