发明名称 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor |
摘要 |
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily. |
申请公布号 |
AU4769793(A) |
申请公布日期 |
1994.01.31 |
申请号 |
AU19930047697 |
申请日期 |
1993.07.01 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
RONALD M EVANS;MICHAEL B MC KEOWN;ANTHONY E ORO;WILLIAM A SEGRAVES;TSO-PANG YAO |
分类号 |
C12N15/09;A61K38/00;A61K48/00;C07K14/44;C07K14/72;C07K19/00;C12N15/12;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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