Methods for detecting autoimmune sensorineural hearing loss

摘要

This invention provides a purified cochlear antigen reactive with an autoantibody associated with autoimmune sensorineuronal hearing loss. The purified antigen is defined as having a molecular weight of about 68,000 daltons as determined by SDS-PAGE analysis under reducing conditions. This invention also provides a method for detecting autoimmune sensorineural hearing loss in a patient. Finally, a kit containing reagents to assay for an antibody associated with autoimmune sensorineural hearing loss in a patient sample is disclosed and claimed by this invention.