Implant prepn., esp. for cartilage repair

摘要

Prepn. of an implant from cell (esp. cartilage cell) cultures comprises: (1) applying the cells to a resorbable, 3-dimensional, shape-stable carrier structure conforming to the shape of the required implant, the carrier having an associated internal surface and small vol.; (2) inserting the cells into the inner cavities of the carrier; (3) coating the cell-loaded carrier with a material that allows diffusion of nutrient soln. through, and (4) perfusing the nutrient soln. for long enough to cause formation of an intercellular matrix that binds the cells together. The new feature is that resorbable microparticles (MP) are included in the carrier, and MP are loaded with a factor (A) that modifies tissue formation. (A) is released as the MP are gradually resorbed.