| 发明名称 |
PREPARATION OF Ag18F AND ITS USE IN THE SYNTHESIS OF PET RADIOTRACERS |
| 摘要 |
Copper-catalyzed radiofluorination of aryl iodides using Ag18F, methods of preparing Ag18F, and compounds obtained by copper-catalyzed radiofluorination of aryl iodides using Ag18F are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed. |
| 申请公布号 |
US2016317682(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201615142131 |
申请日期 |
2016.04.29 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
Scott Peter J. H.;Brooks Allen F.;Ichiishi Naoko;Sanford Melanie S. |
| 分类号 |
A61K51/04;C07C227/16;C01G5/00;C07C17/20 |
主分类号 |
A61K51/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a radiolabeled aryl fluoride comprising:
reacting an aryl iodide having a formula ArI with Ag18F in the presence of a copper source under conditions sufficient to form a radiolabeled aryl fluoride of Formula (1) wherein Ar is an aryl group. |
| 地址 |
Ann Arbor MI US |
