AGENTS MODULATING THE RESPONSE OF NEURONAL CELLS TO INHIBITION BY MAMMALIAN CENTRAL NERVOUS SYSTEM MYELIN

摘要

A method of assaying for a substance which modulates the response of neuronal cells to inhibition by adult central nervous system myelin. Neuronal cells which have a propensity for neurite growth are grown on mammalian central nervous system (CNS) myelin in the presence of a test substance which is suspected of affecting neurite outgrowth. The invention also relates to isolated nucleic acid molecules encoding a novel protein which plays a role in neurite outgrowth. The invention provides for various uses of the nucleic acid molecule and its protein product.