Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of omeprazole

摘要

Pharmaceutical preparation containing omeprazole together with an alkaline compound or an alkaline salt of omeprazole optionally together with an alkaline compound as the core material, one or more subcoating layers comprising inert reacting compounds which are soluble or rapidly disintegrating in water, or polymeric, water soluble filmforming compounds, optionally containing pH-buffering alkaline compounds and an enteric coating as well as a process for the preparation thereof and the use in the treatment of gastrointestinal diseases.