(1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists

摘要

Angiotensin-II antagonists of the formula <IMAGE> wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R3 is, inter alia, lower alkyl; and, R4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: 4'-[(2-n-propyl-4-methyl-6-(1-(2-N-morpholinoethyl)-imidazol-4-yl)-ben zimidazol-1-yl)-methyl]-biphenyl-2-carboxylic acid.