| 发明名称 |
Imidazole containing aminoboronic acids |
| 摘要 |
The present invention relates generally to alpha -aminoboronic acids and corresponding peptide analogs of the formula (I): <IMAGE> (I) in which the alpha -carbon is substituted with an optionally functionalized imidazole containing alkyl group. These compounds are useful as inhibitors of trypsin-like serine protease enzymes, especially thrombin, Factor X and Factor VII.
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| 申请公布号 |
US5639739(A) |
申请公布日期 |
1997.06.17 |
| 申请号 |
US19950409573 |
申请日期 |
1995.03.24 |
| 申请人 |
THE DUPONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
DOMINGUEZ, CELIA;CACCIOLA, JOSEPH;FEVIG, JOHN MATTHEW |
| 分类号 |
A61K38/00;C07F5/02;C07K5/06;(IPC1-7):A61K31/69;C07F5/04;C07K5/065 |
主分类号 |
A61K38/00 |
| 代理机构 |
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| 主权项 |
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