| 发明名称 |
derivados de piperidinona como inibidores mdm2 para o tratamento de câncer |
| 摘要 |
The present invention provides MDM2 inhibitor compounds of Formula IE,
which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor. |
| 申请公布号 |
BR112012030923(A2) |
申请公布日期 |
2016.11.08 |
| 申请号 |
BR20121130923 |
申请日期 |
2011.06.03 |
| 申请人 |
AMGEN INC |
发明人 |
ANA GONZALEZ BUENROSTRO;BENJAMIN FISHER;BRIAN MATTHEW FOX;BRIAN STUART LUCAS;DAQING SUN;DARIN JAMES GUSTIN;DAVID JOHN KOPECKY;DUSTIN MCMINN;FELIX GONZALEZ LOPEZ DE TURISO;FRANK KAYSER;HILARY PLAKE BECK;JASON DUQUETE;JEFFREY DEIGNAN;JEFFREY THOMAS MIHALIC;JIANG ZHU;JIASHENG FU;JIWEN LIU;JOEL MCINTOSH;JOHN EKSTEROWICZ;JONATHAN DANTE LOW;JULIE ANNE HEATH;JULIO CESAR MEDINA;LAWRENCE MCGEE;MICHAEL DAVID BARTBERGER;MICHAEL JOHNSON;MICHAEL WILLIAM GRIBBLE JR.;MING YU;PHILIP MARLEY ROVETO;RICHARD VICTOR CONNORS;STEVEN HOWARD OLSON;SUJEN LAI;XIANYUN JIAO;XIAODONG WANG;XIN HUANG;XUELEI YAN;YIHONG LI;YINGCAI WANG;YOSUP REW;ZHIHONG LI;ZHIHUA MA;ZIAOQI CHEN;ZICE FU |
| 分类号 |
C07D211/40;A61K31/4412;A61P35/00;C07D279/02;C07D401/04;C07D401/06;C07D401/12;C07D407/04;C07D407/06;C07D409/04;C07D413/06;C07D417/06;C07D471/20;C07D498/08;C07D498/20 |
主分类号 |
C07D211/40 |
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